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Wednesday 26 October 2016 Instagram
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Evidence for safety of flu vaccines in over-65s "poor"

Evidence for safety of flu vaccines in over-65s "poor"

Evidence for the safety and efficacy of influenza vaccines in the over-65s is poor, despite the fact that vaccination has been recommended for the prevention of influenza in older people for the past 40 years.

Adults aged 65 and over are some of the most vulnerable during influenza season and a priority for vaccination programmes. However, very few systematic reviews of the effectiveness of vaccines in this group have ever been carried out.

The researchers conducted a thorough search of studies based on previous vaccine trials. Randomized, controlled trials (RCTs) are often considered the "gold standard", but of the 75 studies included in their review, the researchers were only able to identify one recent RCT with "real" outcomes.

In other words, this was the only RCT that used influenza cases as an outcome, as opposed to surrogate outcomes such as measurements of influenza antibodies in the blood. All the other studies included in the review were deemed of low quality and open to bias.

Limited reliable evidence from the studies suggests that the effectiveness of influenza vaccines is modest at best. "Our estimates are consistently below those usually quoted by economists and in decision making," says lead researcher Tom Jefferson of the Cochrane Collaboration in Rome, Italy.

"But until we have all available evidence, it is hard to reach any clear conclusions about the effectiveness of influenza vaccines in older people."

"As the evidence is so scarce at the moment, we should be looking at other strategies to complement vaccinations. Some of these are very simple things like personal hygiene, and adequate food and water," says Jefferson.

"Meanwhile, we need to undertake a high quality, publicly funded trial that runs over several seasons to try to resolve some of the uncertainties we're currently facing."

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