Figures show that there were more than 45,000 incidents relating to the care of children in the NHS in one year, as well as 18,200 cases regarding the care of babies under one month old.
According to a report by the National Patient Safety Agency (NPSA), a majority of the issues were related to "a high rate of medication administration dosing errors", in particular among children under the age of four.
The report shows that 910,089 incidents were reported to the NPSA's Reporting and Learning System (RLS) between 1 October 2007 and 30 September 2008.
A total of 2% were related to the care of babies aged from birth to 27 days and a further 5% were related to children aged from 28 days to 17 years old.
The NPSA said that "only the over-75-year age group had more medication incidents reported" than babies and children aged from birth to four years old.
The report said: "Administration of the incorrect dose or strength of medication was the highest reported medication incident type for both children and neonates."
It found that most of the errors among babies were a result of treatment or procedure at 17%, while 15% of errors were medication incidents, followed by admission, transfer and discharge at 14%.