Incidents of MRSA in England dropped 7% in the last three months of 2008, figures showed.
The number of reported cases between October and December of last year stood at 676, according to the Health Protection Agency (HPA).
This is down from 725 seen between July to September of 2008 and a 38% reduction on the same quarter in 2007, which stood at 1,092 MRSA cases.
An HPA spokeswoman said: "This continued reduction in cases of MRSA is testament to the huge efforts being made across the NHS to tackle the problem of healthcare-associated infections, which remain a big challenge throughout the world.
"To ensure this downward trend continues, we cannot be complacent. We must all play our part - the public and healthcare workers - by ensuring the infection control measures that have made the current fight against MRSA so successful remain in place."