A study of almost three million women found no evidence of an increased risk of menstrual changes after Covid vaccination.
Researchers suggested there was a weak association between the vaccine and menstrual disturbance or premenstrual bleeding, in a paper published in the BMJ.
The authors said that the findings do not provide ‘any substantial support’ for a causal association between the Covid vaccination and healthcare contacts related to menstrual or bleeding disorders.
Many women self-report changes to their periods after a Covid vaccine including excessive, frequent, absent or irregular menstruation, and a link between the vaccine and menstrual disturbance has also been discussed on social media causing global concern.
The researchers in Sweden drew on high-quality health registry data to evaluate the risks of menstrual disturbance and bleeding after the Covid vaccination in 2,946,448 women aged 12-74 from December 2020 to February 2022.
The authors, led by Rickard Ljung, professor at Swedish Medical Products Agency, said: ‘We observed weak and inconsistent associations between SARS-CoV-2 vaccination and healthcare contacts for postmenopausal bleeding, and even less consistent for menstrual disturbance, and premenstrual bleeding.’
The healthcare contacts in the study included primary care visits, specialist outpatient visits, and days of hospital stay related to menstrual disturbance or bleeding before or after menopause.
Pfizer-BioNTech, Moderna, and Oxford-AstraZeneca vaccines were all assessed along with the dose number (unvaccinated and first, second, and third dose).
This was measured over a control period of one to seven days followed by a second time window of eight to 90 days.
More than 88% of women received at least one Covid vaccination and over 64% of vaccinated women received three doses during the study period.
The highest risks for bleeding in post-menopausal women were seen after the third dose in the one to seven-day risk window – some 28% – and in the eight to 90-day risk window – 25%.
The analysis also suggested a 23-33% increased risk of post-menopausal bleeding after eight to 90 days with Pfizer-BioNTech, and Moderna after the third dose, but a less clear association with Oxford-AstraZeneca.
However, the study concluded that after adjusting for socioeconomic factors, previous healthcare use and specific medical conditions, this almost completely removed weak associations, suggesting a casual effect was unlikely.
Meanwhile, a large study concluded that up to one in 20 new cases of diabetes could be linked to Covid infection.
An analysis of records from almost 630,000 people between the beginning of 2020 and the end of 2021 found a significantly higher rate of incident diabetes in those who had PCR-confirmed Covid.
A version of this article was first published on our sister publication, Pulse