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Promotional information from Pierre Fabre Limited


*Based on a clinical study, reduction of blemishes observed under dermatological control with 56 participants. Use of Cleanance Comedomed twice a day for 57 days.

Blemishes: what we see is only the tip of the iceberg

The hidden side of blemishes:


There are two stages in the development of blemishes: the visible stage (comedones) and the invisible stage (microcomedones). Behind one comedone, there are 100 hidden microcomedones, which could turn into comedones.

Cleanance for blemish-prone skin

Watch webinar highlights.

Time to watch: 5 mins 14s

Cleanance Comedomed: an anti-blemish concentrate that mattifies and clears the skin


Cleanance Comedomed is dual action, reducing blemishes and limiting their reappearance, and is highly concentrated in Comedoclastin™ (25%).

Comedoclastin acts to reduce blemishes and prevent their reappearance by blocking the switch for microcomedone formation.

Cleanance Comedomed is composed of 67.5% Avène Thermal Spring Water, which provides softening, soothing and anti-irritating properties.1

Based on an observational clinical study where 90% of patients (n=48) applying Cleanance Comedomed twice daily were without acne relapse at 6 months.

Cleanance Cleansing Gel: deeply cleanses and removes impurities without drying out the skin


Cleanance Cleansing Gel gently purifies and reduces excess sebum, shine and impurities. In addition to a new formula containing Comedoclastin™, Cleanance Cleansing Gel also:

  • contains 84% natural origin ingredients
  • is soap free
  • is well tolerated
  • can be used on the chest, back and face

I have suffered from blemish-prone skin since my early teens; it not only affects my skin, but also my confidence. My dermatologist recently recommended I try Cleanance Comedomed. Since starting to use the Cleanance range my blemishes have reduced and have not reappeared, which has given me back my confidence. Sam, aged 18 years Fictional quote.


  1. Mias C, Maret A et al. Protective properties of Avène thermal spring water on biomechanical, ultrastructural and clinical parameters of human skin. J Eur Acad Dermatol Venereol 2020;34(Suppl 5):15-20
February 2023